DNA methylation is a repressive epigenetic mark vital for normal development. Recent studies have uncovered an unexpected role for the DNA methylome in ensuring the correct targeting of the Polycomb repressive complexes throughout the genome. Here, we discuss the implications of these findings for cancer, where DNA methylation patterns are widely reprogrammed. We speculate that cancer‐associated reprogramming of the DNA methylome leads to an altered Polycomb binding landscape, influencing gene expression by multiple modes. As the Polycomb system is responsible for (...) the regulation of genes with key roles in cell fate decisions and cell cycle regulation, DNA methylation induced Polycomb mis‐targeting could directly drive carcinogenesis and disease progression.Editor's suggested further reading in BioEssays Unmasking risk loci: DNA methylation illuminates the biology of cancer predisposition Abstract. (shrink)

We investigate the notion of relevance as it pertains to ‘commonsense’, subjunctive conditionals. Relevance is taken here as a relation between a property (such as having a broken wing) and a conditional (such as birds typically fly). Specifically, we explore a notion of ‘causative’ relevance, distinct from ‘evidential’ relevance found, for example, in probabilistic approaches. A series of postulates characterising a minimal, parsimonious concept of relevance is developed. Along the way we argue that no purely logical account of relevance (even (...) at the metalevel) is possible. Finally, and with minimal restrictions, an explicit definition that agrees with the postulates is given. (shrink)

This essay examines asset development for the poor as an approach to reducing poverty. Because there has been very little discussion of this approach by Christian ethicists, my primary purpose is to introduce and defend the rationale for developing assets for the poor. I begin with a discussion of conservative and liberal approaches to poverty reduction, arguing that the favored policies of both are founded upon the belief that poverty is best understood as a state of consumption deprivation brought on (...) by deficient levels of income. I suggest that the focus on consumption and income, while obviously important in light of the material deprivations of the poor, is not in itself a sufficient response to the needs of the poor. This leads to a discussion of past and present public policies that have stimulated asset development. A characteristic feature of many of these policies is that they have provided both material and institutional support for asset development, but only for the nonpoor. If public policies have helped the nonpoor to save, why should we not develop policies that help the poor do the same? Some suggested approaches to developing assets for the poor are then reviewed. Finally, I briefly discuss points of convergence between Catholic social thought and asset-development approaches to poverty reduction. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Kenneth Burke on Dialectical-Rhetorical TranscendenceJames P. ZappenKenneth Burke's concept of rhetoric is complex and elusive, increasingly so as it becomes intertwined and infused with dialectic in the long third part of A Rhetoric of Motives and in some essays published shortly thereafter (1951; 1955; 1969b [1950], 183–333).1 The connection between Burke's rhetoric and dialectic is well established (Brummett 1995; Crusius 1986; 1999, 120–21; Wess 1996, 136–216; Wolin 2001, 143–204), (...) and his concept of rhetoric as identification is widely recognized for its broadening of the traditional view of rhetoric as persuasion to include identification as a means of inducing cooperation and building communities (Crusius 1999, 120–21; Hauser 1986, 120–37; Henderson 1988, 33–34). Timothy W. Crusius establishes the fundamental relationship between A Grammar of Motives and A Rhetoric of Motives as dialectical and rhetorical counterparts and explains both the strengths and the limitations of identification as a means of inducing cooperation (1986). According to Crusius, dialectic explores the substance of a person or thing—all that "supports or 'substands'" it—from multiple and shifting perspectives, viewing human action dramatistically as act, scene, agent, agency, and purpose (24–28). Rhetoric complements dialectic and its multiple dramatistic perspectives by promoting "identification" and "cooperation," building "a community, a sense of oneness amid diversity of conflicting interests and values" (28–30). As Crusius and others observe, [End Page 279] however, identification as a means of inducing cooperation is inherently limited since any identification necessarily also entails a division: "Every 'us' requires a 'them'" (29; Biesecker 1997, 47–49; Wolin 2001, 177–78). Thus, for example, while Christianity provides a powerful instance of identification, it also provides an equally powerful illustration of its division from other peoples—"Satan and his counter-kingdom," "the Turk infidel," and "the pagan hordes of Asia" (28–29). For Burke, these divisions were largely political (George and Selzer 2007, 16–57, 110–32; Lentricchia 1983, 21–38). For us, they are differences of gender, culture, and economic and social class (Condit 1992), compounded by political, economic, and religious differences on a global scale. By this account, the first two parts of the Rhetoric offer at best a partial solution to the problem. The third part challenges and mystifies and in itself seems to offer little more than a utopian vision without purpose or outcome (Crusius 1999, 120–21; Wess 1996, 211–16; Wolin 2001, 201–3).2 Situated within the broader context of Burke's work, however, the third part seems rather to offer a bold and creative solution to the problem by merging dialectic and rhetoric with dialogue and poetic myth in a dialectical-rhetorical transcendence—a concept that merits a place alongside identification as a major contribution to rhetorical theory (1969b, 197–208, 221–33).3Burke's concept of dialectical-rhetorical transcendence developed over the course of more than twenty years, from the mid 1930s to the mid 1950s and beyond. Its sources are partly Hegelian and Marxist but increasingly Platonic,4 as Burke comes to perceive the Hegelian and Marxist concepts of history as part of the problem of competing ideologies and his version of Platonic transcendence as the solution—a solution that leads, on the one hand, toward "pure persuasion" and "ultimate identification" and, on the other, toward the pragmatics of a new rhetoric and a revolutionary program of lifelong education (1951; 1955; 1969b, 267–94, 328–33; Biesecker 1997, 43–47; Lee 2004; Wess 1996, 203–5, 211–16; Wolin 2001, 201–3). In the midst of the political divisiveness of the 1930s, Burke glimpsed in Hegel and even Marx the possibility of bridging conflicting ideologies via transcendence, but he turned to Plato in the Grammar and again in the Rhetoric to explain the processes by which opposing ideas and ideologies might merge in transcendent visions or myths that encompass what he perceived to be partial and partisan points of view. In the Grammar, his solution is dialectical—a merger of opposing ideas at higher levels of generalization through a process of linguistic abstraction and transformation that respects a diversity of individual interests, even as it seeks to transcend them in larger [End... (shrink)

ABSTRACT I explore the viability of a Galilean relational theory of space-time—a theory that includes a three-place collinearity relation among its stock of basic relations. Two formal results are established. First, I prove the existence of a class of dynamically possible models of Newtonian mechanics in which collinearity is uninstantiated. Second, I prove that the dynamical properties of Newtonian systems fail to supervene on their Galilean relations. On the basis of these two results, I argue that Galilean relational space-time is (...) too weak of a structure to support a relational interpretation of classical mechanics. 1.Introduction 2.Completeness 3.Leibnizian Relationalism 4.Galilean Relationalism 5.Inverse-Cube Force Laws 5.1Warm-up 5.2Model 1: Zero angular momentum 5.3Model 2: Non-zero angular momentum 6.Supervenience 7.Incompleteness 8.Conclusion. (shrink)

Thousands of texts discuss Egytpain cosmology and cosmogony. James Allen has selected sixteen to translate and discuss in order to shed light on one of the questions that clearly preoccupied ancient intellectuals; the origins of the world.

Using yet untapped resources from moral and political philosophy, this book seeks to answer the question of whether an all good God who is presumed to be all powerful is logically compatible with the degree and amount of moral and natural evil that exists in our world. It is widely held by theists and atheists alike that it may be logically impossible for an all good, all powerful God to create a world with moral agents like ourselves that does not (...) also have at least some moral evil in it. James P. Sterba focuses on the further question of whether God is logically compatible with the degree and amount of moral and natural evil that exists in our world. The negative answer he provides marks a new stage in the age-old debate about God's existence. (shrink)

George Berkeley (1685–1753) believed that the visible world was a series of signs that constituted a divine language through which God was speaking to us. Given the nature of language and the nature of the visual world, this paper examines to what extent the visual world could be a divine language and to what extent God could speak to us through it.

David Hume (1711-1776) and Jonathan Edwards (1703- 1758) had very different reputations concerning the Christian faith. In spite of this, they both had very similar positions concerning miracles and the supernatural. It is argued that although Hume rejects one type of miracle, he acknowledges another type. Edwards does essentially the same thing and rejects the same kind of miracle that Hume rejects, while acknowledging the kind of miracles that Hume acknowledges.

A provocative, insightful explanation for why it is that belief—not religion—keeps us in a perilous state of willful ignorance In The Religious Case Against Belief , James Carse identifies the twenty-first century’s most forbidding villain: belief. In distinguishing religions from belief systems, Carse works to reveal how belief—with its restriction on thought and encouragement of hostility—has corrupted religion and spawned violence the world over. Galileo, Martin Luther, Abraham Lincoln, and Jesus Christ—using their stories Carse creates his own brand of (...) parable and establishes a new vocabulary with which to study conflict in the modern world. The Religious Case Against Belief introduces three kinds of ignorance: ordinary ignorance (a mundane lack of knowledge, such as ignorance of tomorrow’s weather or the reason why your stove is malfunctioning), willful ignorance (an intentional avoidance of accessible knowledge), and finally higher ignorance (a learned understanding that no matter how many truths we may accumulate, our knowledge falls infinitely short of the truth). While ordinary ignorance is common to all people, Carse associates the strongest manifestation of willful ignorance with the most fervent (and dangerous) of believers. He points to the historic conflict between Martin Luther and Holy Roman Emperor Charles V both to reveal this seemingly religious collision as a clash of belief and to identify belief ’s inherently destructive characteristics. From Luther to the contemporary Christian right, we learn that believers construct identity by erecting boundaries and by fostering aggression between the believer and the other. This is why belief systems choose—at great cost—to remain locked in bloody conflict rather than to engage in dialogue, recognizing the great deal they have in common. This is willful ignorance. In fierce contrast to willful ignorance, higher ignorance is an acquired state enhanced by religion. Those traveling the path to higher ignorance recognize faith teachings (such as the Bible) as poetry intended to promote contemplation, interpretation, and a sense of wonder. For evidence of religion’s deeply embedded rejection of singular truth and its acceptance of diverse dialogue, Carse looks to the many faces of Jesus presented in the books of the Bible and elsewhere. Uncontaminated by belief systems, religion rejects the imagined boundaries that falsely divide people and ideas, working to expand horizons. The Religious Case Against Belief exposes a world in which religion and belief have become erroneously (and terrifyingly) conflated. In strengthening their association with powerful belief systems, religions have departed from their essential purpose as agencies of higher ignorance. Carse uses his wideranging understanding of religion to find a viable and vital path away from what he calls the Age of Faith II and toward open-ended global dialogue. Far from abstract philosophical musing, The Religious Case Against Belief is required reading for our age. (shrink)

One of the standard principles of rationality guiding traditional accounts of belief change is the principle of minimal change: a reasoner's belief corpus should be modified in a minimal fashion when assimilating new information. This rationality principle has stood belief change in good stead. However, it does not deal properly with all belief change scenarios. We introduce a novel account of belief change motivated by one of Grice's maxims of conversational implicature: the reasoner's belief corpus is modified in a minimal (...) fashion to assimilate exactly the new information. In this form of belief change, when the reasoner revises by new information p ∨ q their belief corpus is modified so that p∨q is believed but stronger propositions like p∧q are not, no matter what beliefs are in the reasoner's initial corpus. We term this conservative belief change since the revised belief corpus is a conservative extension of the original belief corpus given the new information. (shrink)

This paper describes an approach for reasoning in a dynamic domain with nondeterministic actions in which an agent’s beliefs correspond to the simplest, or most plausible, course of events consistent with the agent’s observations and beliefs. The account is based on an epistemic extension of the situation calculus, a first-order theory of reasoning about action that accommodates sensing actions. In particular, the account is based on a qualitative theory of nondeterminism. Our position is that for commonsense reasoning, the world is (...) most usefully regarded as deterministic, and that nondeterminism is an epistemic phenomenon, arising from an agent’s limited awareness and perception. The account offers several advantages: an agent has a set of categorical beliefs, yet can deal with equally-likely outcomes or with outcomes of differing plausibility. The agent maintains as its set of contingent beliefs the most plausible, or simplest, picture of the world, consistent with its beliefs and actions it believes it executed; yet it may modify these in light of later information. (shrink)

Seven important essays on the study of ancient Egyptian religion. Contents: The cosmology of the pyramid texts (James P Allen); Textual criticism in the coffin texts (David P Silverman); State and religion in the New Kingdom (Jan Assmann); The natural philosophy of Akhenaten (James P Allen); Horus or the crocodiles: a juncture of religion and magic in late Dynastic Egypt (Robert K Ritner); Psychology and society in the ancient Egyptian cult of the dead (Alan B Lloyd); Death and (...) initiation in the funerary reliion of ancient Egypt. (shrink)

This volume provides an introduction to word and paradigm models of morphology and the general perspectives on linguistic morphology that they embody. The recent revitalization of these models is placed in the larger context of the intellectual lineage that extends from classical grammars to current information-theoretic and discriminative learning paradigms. The synthesis of this tradition outlined in the volume highlights leading ideas about the organization of morphological systems that are shared by word and paradigm approaches, along with strategies that have (...) been developed to formalize these ideas, and ways in which the ideas have been validated by experimental methodologies. An extended comparison of contemporary word and paradigm variants isolates the central assumptions about morphological units and relations that distinguish implicational from realizational models and clarifies the relation of these models to morpheme-based accounts. Designed to be accessible to a wide readership, this book will serve both as an introduction to morphology and morphological theory from the word and paradigm perspective for non-specialists, and for morphologists, as a detailed account of the history of the ideas that underlie these models. (shrink)

James P. Sterba offers something that philosophers have long sought: an argument showing that morality is rationally required. Furthermore he argues that morality requires substantial equality. Even libertarian perspectives, which would seem to require minimal enforcement of morality, are shown to lead to a requirement of equality.

Philosophy evolves as the philosophical imagination of thinkers seek answers to emerging data and circumstances that inherited perspectives did not provide. This short history of philosophy shows how materialism, immaterialism, rationalism, empiricism, phenomenalism, historicism, existentialism, pragmatism, hermeneutics, the linguistic turn, and feminism developed to sharpen and enlarge the modern mind.

"Contrasts the conceptual understanding we inherit from our culture and language community (first truth) with the more sophisticated understanding we gain through personal experience, searching, and philosophical questioning (second truth). Socrates and Jesus are described as persons who are exemplary in application of their second truths.